Friday, February 24, 2017

University of Guelph Melatonin Study: Examining the Vast Differences

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University of Guelph Melatonin Study: Examining the Vast Differences  


Last week, the University of Guelph published findings of their study on different varieties of melatonin. The university tested 30 different melatonin supplements from 16 brand names. The supplements were sold in grocery stores and drug stores. Of the products tested, 71 percent did not meet their label claims. Some examples of these inaccuracies are listed below:
  • 12-25 percent had higher than listed melatonin amounts
  • Some products contained almost 5 times the listed amount of melatonin
  • One chewable tablet that listed 1.5 mg of melatonin actually contained over 8 mg of melatonin
  • Some products skewed the other way, containing less melatonin than listed
  • One product listed 3 mg melatonin but contained 83 percent less
  • One quarter of the supplements also contained serotonin, which is not authorized to be sold as a supplement, as it could be dangerous for those on SSRI's.
In the article, doctors commenting on the findings noted that as an unstable molecule, melatonin could be affected by environmental conditions (such as temperature) or differences among batches (such as by improper mixing). The doctors speculated that feasibly some manufacturers may have added extra melatonin in an attempt to extend the product's shelf life. Their final conclusion was their hope that these findings could help manufacturers improve production quality.

Sadly, findings such as these are not new, and confirm yet again what we have said all along. Raw material quality matters and manufacturing should be performed responsibly. Life Choice only uses USP pharmaceutical grade raw materials and manufactures at GMP facilities.

There are 3 grades for raw material: pharmaceutical (which meets pharmaceutical standards of purity 97.5%+); food grade, which meets the standards for human consumption (more added fillers); and feed grade, which meets the standards for animal consumption (low quality, not much regulation). The lower grades are mixed with fillers, etc. and the amount put in the capsule will be more likely to vary (at times, vary widely, as the study shows), while the USP standard must be pure and exact--this makes all the difference in what people's experience with melatonin will be.

We use only 100% DMF (drug master file) patented pharmaceutical grade melatonin; we pay 700% more for our raw material than for material that can be purchased without a patent. Why? The reasons are twofold: first, the material is clinically researched, and secondly, the quality is consistently high with each order. Small batch manufacturing and the selection of raw materials create the difference that your body will notice. After the raw material stage, all our products are manufactured at third party GMP facilities, and then third party tested. We do everything in our power to ensure that the label matches the contents.

Another reason for the huge difference is the large batch blending and the improper distribution of the active material. If we consider the active as being 3 mg, when encapsulated in the standard  size “2” capsule, the total fill weight will be 370 mg with 367 mgs of fillers, and in tablets, the fillers are even more. If encapsulated in size “0,” the total fill weight would be 680 mg or 677 mg of filler. In perspective, a large pharmaceutical company would run a minimum of 100 million plus capsules, using 300 kgs of melatonin and 36,900 kgs of filler. It is perfectly understandable why each capsule is vastly different in the melatonin content, for blending equally is next to impossible. Life Choice produces small batch runs of 133,000 capsules and encapsulate into size “4” vegetarian capsules with a total fill weight of 210 mg. This lower yield gives an equal distribution of melatonin per capsule.          

If you have had bad experiences with melatonin, could it be because the melatonin was carelessly manufactured? Environmental toxins can affect the unstable molecule that releases melatonin from the pineal gland. Melatonin is a hormone, and because it is, it must be USP pharmaceutical grade. Otherwise, users run the risk of nightmares and other bad experiences. Have you tried our Melapure Melatonin? Available in both capsule and liquid forms, every aspect of Melapure Melatonin is made with the utmost care. If you are looking for a better melatonin experience, try Melapure today.

With over 10 years of experience, Bond Consulting is a leader in the SR&ED industry. The SR&ED program is designed to support innovative companies with cash reimbursements from the Canadian Government due to their private R&D efforts. (

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