Friday, February 24, 2017

University of Guelph Melatonin Study: Examining the Vast Differences

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University of Guelph Melatonin Study: Examining the Vast Differences  

 

Last week, the University of Guelph published findings of their study on different varieties of melatonin. The university tested 30 different melatonin supplements from 16 brand names. The supplements were sold in grocery stores and drug stores. Of the products tested, 71 percent did not meet their label claims. Some examples of these inaccuracies are listed below:
  • 12-25 percent had higher than listed melatonin amounts
  • Some products contained almost 5 times the listed amount of melatonin
  • One chewable tablet that listed 1.5 mg of melatonin actually contained over 8 mg of melatonin
  • Some products skewed the other way, containing less melatonin than listed
  • One product listed 3 mg melatonin but contained 83 percent less
  • One quarter of the supplements also contained serotonin, which is not authorized to be sold as a supplement, as it could be dangerous for those on SSRI's.
In the article, doctors commenting on the findings noted that as an unstable molecule, melatonin could be affected by environmental conditions (such as temperature) or differences among batches (such as by improper mixing). The doctors speculated that feasibly some manufacturers may have added extra melatonin in an attempt to extend the product's shelf life. Their final conclusion was their hope that these findings could help manufacturers improve production quality.

Sadly, findings such as these are not new, and confirm yet again what we have said all along. Raw material quality matters and manufacturing should be performed responsibly. Life Choice only uses USP pharmaceutical grade raw materials and manufactures at GMP facilities.

There are 3 grades for raw material: pharmaceutical (which meets pharmaceutical standards of purity 97.5%+); food grade, which meets the standards for human consumption (more added fillers); and feed grade, which meets the standards for animal consumption (low quality, not much regulation). The lower grades are mixed with fillers, etc. and the amount put in the capsule will be more likely to vary (at times, vary widely, as the study shows), while the USP standard must be pure and exact--this makes all the difference in what people's experience with melatonin will be.

We use only 100% DMF (drug master file) patented pharmaceutical grade melatonin; we pay 700% more for our raw material than for material that can be purchased without a patent. Why? The reasons are twofold: first, the material is clinically researched, and secondly, the quality is consistently high with each order. Small batch manufacturing and the selection of raw materials create the difference that your body will notice. After the raw material stage, all our products are manufactured at third party GMP facilities, and then third party tested. We do everything in our power to ensure that the label matches the contents.

Another reason for the huge difference is the large batch blending and the improper distribution of the active material. If we consider the active as being 3 mg, when encapsulated in the standard  size “2” capsule, the total fill weight will be 370 mg with 367 mgs of fillers, and in tablets, the fillers are even more. If encapsulated in size “0,” the total fill weight would be 680 mg or 677 mg of filler. In perspective, a large pharmaceutical company would run a minimum of 100 million plus capsules, using 300 kgs of melatonin and 36,900 kgs of filler. It is perfectly understandable why each capsule is vastly different in the melatonin content, for blending equally is next to impossible. Life Choice produces small batch runs of 133,000 capsules and encapsulate into size “4” vegetarian capsules with a total fill weight of 210 mg. This lower yield gives an equal distribution of melatonin per capsule.          

If you have had bad experiences with melatonin, could it be because the melatonin was carelessly manufactured? Environmental toxins can affect the unstable molecule that releases melatonin from the pineal gland. Melatonin is a hormone, and because it is, it must be USP pharmaceutical grade. Otherwise, users run the risk of nightmares and other bad experiences. Have you tried our Melapure Melatonin? Available in both capsule and liquid forms, every aspect of Melapure Melatonin is made with the utmost care. If you are looking for a better melatonin experience, try Melapure today.
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With over 10 years of experience, Bond Consulting is a leader in the SR&ED industry. The SR&ED program is designed to support innovative companies with cash reimbursements from the Canadian Government due to their private R&D efforts. (www.bondconsulting.ca)





Copyright © *|2016|* *|Doctor's Choice TM|*, All rights reserved.


Our Contact Info is:
Address: P.O. Box 1696 Station Main, Cochrane, AB T4C 1B6
Tel: 866-226-1722
Fax: 866-226-1822
E-mail: info@doctorschoice.ca
Web: www.doctorschoice.ca

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Monday, February 20, 2017

Health News: Doctor's Choice Opens A New Clinic Room At The CCNM

Life Choice founder and CEO Eldon Dahl, (Doctorate of natural medicine) is pleased to announce that Life Choice Ltd has - under its Doctor’s Choice® label -  sponsored and opened a clinic room at the Canadian College of Natural Medicine (CCNM).




ribbon cutting dedication ceremony for the opening of the
Doctor’s Choice® clinic room at CCNM




When asked about their sponsorship and new clinic room, Dahl responded by saying, “The future of natural medicine lies within the hands of the next generation of naturopathic doctors. We find it an honour and a privilege to assist these highly trained medical professionals – they stand as our only holistic healthcare alternative to allopathic (prescription drug) medicine. They are an integral part of keeping Canadians healthier by offering preventative advice and natural medical treatment for a more enjoyable lifestyle. With our continued support, we believe they can reach their healthcare goals."

About

Life Choice® is a leader in the manufacturing and supply of top quality nutraceuticals. The company only manufacturers and supplies the highest quality natural products to markets in Canada, the United States and the European Union. 

All Life Choice®nutraceuticals are clinically tested, government approved and licensed. Every product in the Life Choice® family is formulated under the direct supervision of Eldon Dahl, the company's CEO and founder who possesses a doctorate in natural medicine. 

All of the company's products are professionally formulated to have therapeutic and medicinal value. 

Ask your medical practitioner, naturopath physician, or health food store manger for products carrying the Life Choice label. Or better yet, please visit our 
website and check out our products.



Friday, February 10, 2017

Health Benefits of L-Tryptophan vs. 5-HTP: A Clarification Study ...

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Health Benefits of L-Tryptophan vs. 5-HTP: A Clarification Study  

 

L-Tryptophan is an essential amino acid, used by the pineal gland within the brain to produce serotonin, which is a necessary neurotransmitter that transfers nerve impulses from cell to cell. Tryptophan helps combat depression and insomnia, and it promotes mood stabilization. Studies have shown that Tryptophan supplementation can help neuropsychiatric disorders, while Tryptophan depletion reduces serotonin levels in autistic adults, making their symptoms worse. Tryptophan also helps to control hyperactivity in children, alleviates stress, benefits the heart, aids in weight control (as an appetite suppressant), and enhances the release of growth hormone. Adequate B-6 (P5P form in the Doctor's Choice formula) is necessary within the body for the formation of serotonin. A lack of tryptophan and magnesium may contribute to coronary artery spasms or irregular heartbeats; supplementation can conceivably reduce heart attacks. Tryptophan does not work by drugging or depressing the central nervous system, but by simply returning normal function by being available for the body to use as needed. Foods that contain Tryptophan include brown rice, turkey, peanuts, and soy protein. However, the best way to ensure adequate Tryptophan in the body is supplementation, since this is the only way to cross the blood-brain barrier for absorption in any noticeably higher amount.

You may be wondering, "If Tryptophan is good for such a wide range of issues, why is it not more popular?" The answer is that Tryptophan has been out of circulation until recently.

In 1989, there was a fatal outbreak of eosinophilia myalgia syndrome (EMS). EMS is a rare autoimmune disease that causes fever, numbness, and rashes; it also affects the muscles, arms and legs. In severe cases, EMS can cause death. This outbreak of EMS was traced back to contamination from a new tryptophan processing method that one Japanese manufacturer had implemented. (Doctor's Choice was and is not associated with this manufacturer.) In years prior, tryptophan users never reported any EMS-related symptoms; only those who were unfortunate enough to receive the “bad batch” from 1989 reported health issues. Several of those who developed EMS from the contaminated tryptophan sued the Japanese manufacturer; in fact, some even attempted to further their cause by claiming that their illness and pain continued on after the symptoms were gone. This uproar resulted in a FDA mandate banning the sale of tryptophan in the US. The media, of course, published the “health risks” of tryptophan, as well, which only fueled the fires of panic.

As Dr. Eric Braverman points out in his book, The Healing Nutrients Within, many of those who complained of persisting EMS issues were not screened for muscle-aching disorders, and may have had pre-existing health conditions that affected how their bodies metabolized tryptophan in the first place. Research in recent years has revealed several disorders related to “defective tryptophan metabolism and elevated tryptophan blood levels.” (Braverman, p. 54) Yet, no patients with these conditions were diagnosed with EMS, which means that tryptophan alone could not have caused it. In addition, the FDA’s Center for Food Safety and Applied Nutrition studied amino acid supplementation and concluded that it is safe.

Yet, due in large part to the controversy, prior to December 2011, the sale of L-Tryptophan was reduced to prescription status only.

It was believed that another precursor for serotonin would be a viable substitute. The health professional community and nutrient distributors who supplied it turned to 5-Hydroxy-L-Tryptophan (5-HTP) as the alternative supplement. In fact, 5-HTP has been effective therapy for some, but it has been somewhat troubling as a therapeutic agent. Because it bypasses the body and brain’s regulatory control mechanisms, 5-HTP may put patients at risk for the same heart-valve problems caused by the pharmaceutical diet drug Fen-Phen’. Both promote uncontrolled creation of serotonin. L-Tryptophan can be readily converted to 5-HTP as needed, but 5-HTP is no substitute for L-Tryptophan.
 

Since research has shown that 5-HTP is poorly absorbed across the blood-brain barrier in patients who have ever had major depression (See Diagram 1 above), these individuals would more likely respond to treatment with L-Tryptophan than to 5-HTP treatment. Even when Tryptophan levels are normal, a deficiency of Pyridoxal-5-phosphate (P5P), (a bioavailable form of B-6) will lower Serotonin levels, and in the presence of P5P, brain serotonin levels are increased.

Doctor's Choice L-Tryptophan is the best choice for two reasons: first, raw material sourcing produced by natural fermentation from cane sugar, meaning it is vegan, and certified as being Kosher and Halal. Second, the addition of P5P (Vit. B6). Raw materials matter. Companies are prone to brag on their testing methods, and while testing is great, what is being tested? Where did the product the consumer will be ingesting come from? This topic is not as popular, and for good reason. The easiest way to show how stark the contrast can be is to share the notice below from our amino acid manufacturer (click to enlarge if needed):
While it is shocking to consider the full ramifications of this notice due to having unknown trace residuals from either animal or human, and dependent on the origin of the sewage sludge, it is an important reminder that to truly know the quality of a product, customers may have to do some digging, for all the testing in the world won’t change the product's origin.

Aside from high quality raw materials, the addition of P5P is also important. The brain is protected by the blood-brain barrier, and neurotransmitters are required to shuttle amino acids into the brain. The ratio of amino acids to neurotransmitters is "over
one-to-one thousand in the CNS, with the ultimate effect at the end receptor level . . . The requirement of pyridoxine in the CNS is a 100-fold greater than in the peripheral organs. In humans, an exogenous source of vitamin B6 is required for amino acid
metabolism." In other words, for Tryptophan to get into the brain, it needs P5P to get through the blood-brain barrier.

As we have seen, there is a big difference between 5-HTP and L-Tryptophan, and there is a big difference between generic L-Tryptophan and Doctor's Choice L-Tryptophan. We would encourage you to join others who have followed the science and chosen Doctor's Choice.
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With over 10 years of experience, Bond Consulting is a leader in the SR&ED industry. The SR&ED program is designed to support innovative companies with cash reimbursements from the Canadian Government due to their private R&D efforts. (www.bondconsulting.ca)





Copyright © *|2016|* *|Doctor's Choice TM|*, All rights reserved.


Our Contact Info is:
Address: P.O. Box 1696 Station Main, Cochrane, AB T4C 1B6
Tel: 866-226-1722
Fax: 866-226-1822
E-mail: info@doctorschoice.ca
Web: www.doctorschoice.ca

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The latest news from Doctor's Choice!
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The Effects of Non-GMO Soy in Breast Cancer  

 

Clinical Cancer Research recently published a study on the conflicting reports of soy (genistein) on breast cancer. Although soy has a similar structure to estrogen, which drives most breast cancer growth, women in Asian countries (where much more soy is consumed) have a 5 times lower rate of breast cancer than Western women. The study concluded that while soy should not be started at the onset of breast cancer, if it is taken prior to a cancer diagnosis, it does not have to be stopped--in fact, it can have a protective effect against cancer.

As we have previously stated, our Progest Liposome Cream and Balanced Female have non-GMO soy with active genistein; it is patented and USP pharmaceutical grade. This quality of soy is valuable both for natural HRT and for cancer prevention. All hormones are chemical messengers that are essential to nearly all functions of the body, directing the body to do one thing or another. Progesterone acts as an antagonist to estrogen — it turns estrogen down. It is not the absolute deficiency of estrogen or progesterone but rather the relative dominance of estrogen and relative deficiency of progesterone that is the main cause of hormone-related health problems. From age 35 to 50, there is a 75% reduction in production of progesterone in the body. Estrogen, during the same period, only declines about 35%. By menopause, the total amount of progesterone made is extremely low, while estrogen is still present in the body at about half its premenopausal level. Estrogen and progesterone need the presence of each other in order to correctly perform their individual functions.

Because the study referenced here compares the effects of soy when on Tamoxifen, it is important to note that natural cancer treatment options are available with your local naturopath. Professor Jack Cuzick, an epidemiologist at Queen Mary, University of London, says, "For every 1,000 women on tamoxifen for 10 years, we estimate there would be 20 fewer breast cancers. But there would be three more womb cancers and six more deep vein thromboses." Phytoestrogens, on the other hand, "stimulate oestrogen receptors in the cases of oestrogen deficiency or block oestrogen receptors in the case of oestrogen excess" because of their structural similarity to estrogen. Phytoestrogens can function similarly to Tamoxifen and more, but without the high risk profile. Some studies have also shown that Indole-3-carbinol, a natural compound found in cruciferous vegetables, also functions similarly to Tamoxifen.

As you can see, there are benefits to the natural approach: results can be achieved without side effects. Life Choice hormone balancing products are formulated for the maximum benefit, the natural way.
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With over 10 years of experience, Bond Consulting is a leader in the SR&ED industry. The SR&ED program is designed to support innovative companies with cash reimbursements from the Canadian Government due to their private R&D efforts. (www.bondconsulting.ca)





Copyright © *|2016|* *|Doctor's Choice TM|*, All rights reserved.


Our Contact Info is:
Address: P.O. Box 1696 Station Main, Cochrane, AB T4C 1B6
Tel: 866-226-1722
Fax: 866-226-1822
E-mail: info@doctorschoice.ca
Web: www.doctorschoice.ca

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